LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012437

UniProt Annotations

Entry Information
Gene Namevesicle-associated membrane protein 2
Protein EntryVAMP2_RAT
UniProt IDP63045
SpeciesRat
Comments
Comment typeDescription
FunctionInvolved in the targeting and/or fusion of transport vesicles to their target membrane
InteractionSelf; NbExp=2; IntAct=EBI-520880, EBI-520880; D4A229:Prkd3; NbExp=2; IntAct=EBI-520880, EBI-1255458; P32851:Stx1a; NbExp=5; IntAct=EBI-520880, EBI-539720;
SimilarityBelongs to the synaptobrevin family
SimilarityContains 1 v-SNARE coiled-coil homology domain
Subcellular LocationCytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Note=Neuronal synaptic vesicles.
SubunitPart of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Interacts with BVES and STX4. Interacts with VAPA and VAPB (By similarity)
Tissue SpecificityNervous system specific. A higher level expression is seen in the brain as compared to the spinal cord