LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012396

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 11, subfamily b, polypeptide 2
Protein Entry
UniProt ID
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityA steroid + 2 reduced adrenodoxin + O(2) + 2 H(+) = an 11-beta- hydroxysteroid + 2 oxidized adrenodoxin + H(2)O. {ECO:0000250|UniProtKB:P19099}.
Catalytic ActivityCorticosterone + 2 reduced adrenodoxin + O(2) + 2 H(+) = 18-hydroxycorticosterone + 2 oxidized adrenodoxin + H(2)O. {ECO:0000250|UniProtKB:P19099}.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250|UniProtKB:P19099};
FunctionConverts 11-deoxycorticosterone into corticosterone, 18- hydroxycorticosterone, and aldosterone. Also can catalyze the conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and cortisone.
InductionA 12-fold increase was seen in the presence of a low sodium-high potassium diet. {ECO:0000269|PubMed:8468320}.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationMitochondrion membrane.
Tissue SpecificityAdrenal cortex.