LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP011866

UniProt Annotations

Entry Information
Gene Namevac14 homolog (S. cerevisiae)
Protein EntryVAC14_DANRE
UniProt IDQ66L58
SpeciesZebrafish
Comments
Comment typeDescription
FunctionThe PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity (By similarity). {ECO:0000250}.
SimilarityBelongs to the VAC14 family. {ECO:0000305}.
SimilarityContains 6 HEAT repeats. {ECO:0000305}.
Subcellular LocationEndosome membrane {ECO:0000250}.
SubunitComponent of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold (By similarity). {ECO:0000250}.