LIPID MAPS® Gene/Proteome Database (LMPD)

Introduction | Overview of Interfaces | Browse | Search | Download

LMPD Record

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP011620

UniProt Annotations

Entry Information
Gene Nameprogestin and adipoQ receptor family member VII, b
Protein EntryMPRAB_DANRE
UniProt IDQ801G2
SpeciesZebrafish
Comments
Comment typeDescription
Developmental StageIn oocytes, expression is lowest in ovarian follicles at stages I and II but gradually increases after the onset of vitellogenic growth, peaking at vitellogenic stages (stage IIIB). {ECO:0000269|PubMed:15862564}.
FunctionSteroid membrane receptor. Signals upon progestin binding, resulting in rapid activation of MAPK and down-regulation of adenylyl cyclase activity. Interacts with steroids with varying degrees of affinity, showing specificity for activation by the maturation-inducing steroid (MIS) 4-pregnen-17,20beta-diol-3-one (17,20beta-DHP). Capable of mediating progestin-induced oocyte maturation. {ECO:0000269|PubMed:12574519, ECO:0000269|PubMed:16899559}.
SimilarityBelongs to the ADIPOR family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:16899559}; Multi-pass membrane protein {ECO:0000269|PubMed:16899559}.