LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP010516

UniProt Annotations

Entry Information
Gene Nameinositol-tetrakisphosphate 1-kinase 4
Protein EntryITPK4_ARATH
UniProt IDO80568
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
Catalytic ActivityATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate.
Catalytic ActivityATP + 1D-myo-inositol 3,4,5,6- tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6- pentakisphosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 2 magnesium ions per subunit. {ECO:0000250};
FunctionKinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAC23406.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the ITPK1 family. {ECO:0000305}.
SimilarityContains 1 ATP-grasp domain. {ECO:0000305}.
SubunitMonomer. {ECO:0000250}.