LIPID MAPS® Gene/Proteome Database (LMPD)

Introduction | Overview of Interfaces | Browse | Search | Download

LMPD Record

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP010514

UniProt Annotations

Entry Information
Gene Nameinositol-tetrakisphosphate 1-kinase 1
Protein EntryITPK1_ARATH
UniProt IDQ9SBA5
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate. {ECO:0000269|PubMed:9126335}.
Catalytic ActivityATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate. {ECO:0000269|PubMed:9126335}.
Catalytic ActivityATP + 1D-myo-inositol 3,4,5,6- tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6- pentakisphosphate. {ECO:0000269|PubMed:9126335}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 2 magnesium ions per subunit. {ECO:0000250};
FunctionKinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not (By similarity). Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. {ECO:0000250}.
SimilarityBelongs to the ITPK1 family. {ECO:0000305}.
SimilarityContains 1 ATP-grasp domain. {ECO:0000255|PROSITE- ProRule:PRU00409}.
SubunitMonomer. {ECO:0000250}.