LMP010507 UniProt Annotations
Gene Name inositol-pentakisphosphate 2-kinase 1
Protein Entry IPPK_ARATH
UniProt ID Q93YN9
Species Arabidopsis
Comment type Description
Biophysicochemical Properties Kinetic parameters: KM=38 uM for Ins(1,3,4,5,6)P5 (in the presence of 0.4 mM ATP) {ECO:0000269|PubMed:16223361}; KM=176 uM for Ins(1,3,4,5,6)P5 (in the presence of 0.4 uM ATP) {ECO:0000269|PubMed:16223361}; Vmax=22 nmol/min/mg enzyme (in the presence of 0.4 mM ATP) {ECO:0000269|PubMed:16223361}; Vmax=1.5 nmol/min/mg enzyme (in the presence of 0.4 uM ATP) {ECO:0000269|PubMed:16223361};
Biotechnology The gene coding for this protein might be inactivated to commercially produce plants with phytate-free grain. Indeed, while the role of phytate (InsP6) accumulation in seeds is unknown, it causes nutritional and environmental problems, partly due to the inability of monogastric animals to digest it.
Catalytic Activity ATP + 1D-myo-inositol 1,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate. {ECO:0000269|PubMed:16107538, ECO:0000269|PubMed:16223361}.
Domain The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Function Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5. {ECO:0000269|PubMed:16107538, ECO:0000269|PubMed:16223361}.
Sequence Caution Sequence=BAB10637.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the IPK1 type 2 family. {ECO:0000305}.
Tissue Specificity Strongly expressed in leaves and cauline leaves. Weakly expressed in siliques and flowers. In flower, it is expressed in the major organs of developing flower buds. Strongly expressed in sepals, petals, in the male and female organs of immature and mature flower buds. Strongly expressed in the gynoecium and carpels which are fused to form the gynoecium. Also expressed in the transmitting tissue and ovules. {ECO:0000269|PubMed:16223361}.
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