LMP010504 UniProt Annotations
Gene Name inositol polyphosphate multikinase beta
Protein Entry IPMKB_ARATH
UniProt ID Q9FLT2
Species Arabidopsis
Comment type Description
Catalytic Activity 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.
Catalytic Activity ATP + 1D-myo-inositol 1,3,4,6- tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6- pentakisphosphate.
Developmental Stage Expressed in mature pollen, but not in immature pollen grains. {ECO:0000269|PubMed:12566584}.
Disruption Phenotype Loss-of-function mutant atIpk2beta-1 (T-DNA insertion) is fully complemented by AtIPK2alpha in tissue but not in seeds, leading to the generation of phytate-free seeds. {ECO:0000269|PubMed:16107538}.
Function Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4), inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4), inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) and inositol 1,2,3,4,6-pentakisphosphate (Ins(1,2,3,4,6)P5) but not inositol 1,4-bisphosphate (Ins(1,4)P2), inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), inositol 1,2,6- trisphosphate (Ins(1,2,6)P3), inositol 3,4,5,6-tetrakisphosphate (Ins(3,4,5,6)P4), inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5), inositol 1,2,4,5,6-pentakisphosphate (Ins(1,2,4,5,6)P5) or inositol hexakisphosphate (InsP6). Involved in the auxin signaling pathway. Regulates axillary shoot branching and is required for phytate synthesis in seeds. {ECO:0000269|PubMed:12226109, ECO:0000269|PubMed:16107538, ECO:0000269|PubMed:17434984}.
Induction Induced by auxin, but not by salt, abscisic acid, manitol, water or drought. {ECO:0000269|PubMed:12566584, ECO:0000269|PubMed:17434984}.
Miscellaneous Does not bind calmodulin.
Ptm Phosphorylated. {ECO:0000269|PubMed:12566584}.
Similarity Belongs to the inositol phosphokinase (IPK) family. {ECO:0000305}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12566584}.
Tissue Specificity Expressed in leaves, stems, roots, siliques and flowers. Detected in vascular strands, stigma cells, the abscission zones of fully elongated siliques, the root central cylinder and the root tip. {ECO:0000269|PubMed:12226109, ECO:0000269|PubMed:12566584}.
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