LIPID MAPS® Gene/Proteome Database (LMPD)

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LMP010448

UniProt Annotations

Entry Information

Gene Name	G-protein-coupled receptor 1
Protein Entry	GCR1_ARATH
UniProt ID	O04714
Species	Arabidopsis

Comments

Comment type	Description
Developmental Stage	In seedlings, mostly expressed in small roots, and to a lower extent in hypocotyls. In young plants, equaly expressed in leaves, roots, and shoot tip. In old plants, present in roots, flower buds and young siliques, but not in leaves. {ECO:0000269\|PubMed:11930019}.
Disruption Phenotype	Hypersensitivity to abscisic acid (ABA) and to the lipid metabolite, sphingosine-1-phosphate (S1P), a transducer of the ABA signal. Improved drought tolerance accompanied by lower rates of water loss. Impaired sensitivity to gibberellin (GA) and brassinosteroid (BR) in seed germination. Hypersensitivity to ABA and glucose (Glc) during and after seed germination. Altered response to blue light (BL). {ECO:0000269\|PubMed:15155892, ECO:0000269\|PubMed:15181210, ECO:0000269\|PubMed:16415218, ECO:0000269\|PubMed:16581874, ECO:0000269\|PubMed:17322342}.
Function	Together with GPA1, may regulate the cell cycle via a signaling cascade that uses phosphatidylinositol-specific phospholipase C (PI-PLC) as an effector and inositol 1,4,5- trisphosphate(IP(3)) as a second messenger. Acts as a negative regulator of GPA1-mediated abscisic acid (ABA) responses in guard cells, and together with GPA1 and GB1 during seed germination and early seedling development. Promotes PI-PLC activity and IP(3) accumulation. Involved in the blue light (BL) signaling. Together with GPA1 and ADT3, required for BL-mediated synthesis of phenylpyruvate and subsequently of phenylalanine (Phe), in etiolated seedlings. Probably involved in cytokinin signal transduction. Plays a positive role in gibberellin- (GA) and brassinosteroid- (BR) regulated seed germination, probably independently of a heterotrimeric G-protein. Mediates seed dormancy abolition, and promotes seed germination and flowering. {ECO:0000269\|PubMed:11930019, ECO:0000269\|PubMed:12972659, ECO:0000269\|PubMed:15155892, ECO:0000269\|PubMed:15181210, ECO:0000269\|PubMed:16415218, ECO:0000269\|PubMed:16581874, ECO:0000269\|PubMed:17322342, ECO:0000269\|PubMed:9512416}.
Induction	Modulated during the cell cycle with a peak during the early G(1) phase. Induced upon imbibition. {ECO:0000269\|PubMed:11930019, ECO:0000269\|PubMed:16581874}.
Interaction	P18064:GPA1; NbExp=6; IntAct=EBI-443899, EBI-443890;
Similarity	Belongs to the G-protein coupled receptor 2 family. {ECO:0000305}.
Subcellular Location	Cell membrane {ECO:0000269\|PubMed:15181210, ECO:0000269\|Ref.7}; Multi-pass membrane protein {ECO:0000269\|PubMed:15181210, ECO:0000269\|Ref.7}. Note=Localized to the outer edge of the leaf epidermal cells in a punctuate pattern.
Subunit	Interacts with GPA1. {ECO:0000269\|PubMed:15155892}.
Tissue Specificity	Mostly present in the meristematic regions. Expressed at low levels in seedlings, vascular tissues of cotyledons, hypocotyl, and roots, stems, leaves, flowering buds and siliques. In dark-grown seedlings, localized in the cotyledons and the hook. {ECO:0000269\|PubMed:11930019, ECO:0000269\|PubMed:15181210, ECO:0000269\|PubMed:9512416}.