LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP009946

UniProt Annotations

Entry Information
Gene Namemyo-inositol monophosphatase like 2
Protein EntryHIS7_ARATH
UniProt IDQ6NPM8
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityL-histidinol phosphate + H(2)O = L-histidinol + phosphate.
Catalytic ActivityMyo-inositol phosphate + H(2)O = myo-inositol + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Developmental StageExpressed at all developmental stages. Detected in globular to heart stage embryos. {ECO:0000269|PubMed:20023146, ECO:0000269|PubMed:20960216}.
Disruption PhenotypeEmbryo lethality. {ECO:0000269|PubMed:19339506, ECO:0000269|PubMed:20023146, ECO:0000269|PubMed:20960216}.
FunctionPhosphatase required for histidine production. Acts also on L-galactose 1-phosphate (L-Gal 1-P), D-myoinositol 3-phosphate (D-Ins 3-P) and D-myoinositol 1-phosphate (D-Ins 1-P). {ECO:0000269|PubMed:19339506, ECO:0000269|PubMed:20023146, ECO:0000269|PubMed:20960216}.
MiscellaneousNo redundancy with IMPL1 or VTC4.
PathwayAmino-acid biosynthesis; L-histidine biosynthesis; L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
PathwayPolyol metabolism; myo-inositol biosynthesis; myo- inositol from D-glucose 6-phosphate: step 2/2.
Sequence CautionSequence=AEE87019.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC43548.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB43627.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB80575.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the inositol monophosphatase family. {ECO:0000305}.
Subcellular LocationPlastid, chloroplast {ECO:0000269|PubMed:18431481, ECO:0000269|PubMed:20023146}.
Tissue SpecificityUbiquitous. High expression in roots. Expressed in pistil and seed endosperm. {ECO:0000269|PubMed:20023146, ECO:0000269|PubMed:20960216}.