LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP009800

UniProt Annotations

Entry Information
Gene NameADP-ribosylation factor GTPase-activating protein AGD3
Protein EntryAGD3_ARATH
UniProt IDQ5W7F2
SpeciesArabidopsis
Comments
Comment typeDescription
DomainThe BAR domain is required and sufficient for homodimerization.
FunctionGTPase-activating protein (GAP) for ADP ribosylation factor (ARF). Involved in the spatial control of provascular differentiation. Required for the formation of the normal pattern of continuous secondary veins. Involved in auxin signaling but not in polar auxin transport or in auxin responses. Required for PIN1 internalization in roots. {ECO:0000269|PubMed:10887076, ECO:0000269|PubMed:10887077, ECO:0000269|PubMed:15743878, ECO:0000269|PubMed:16698946}.
InductionUp-regulated by auxin. {ECO:0000269|PubMed:15743878}.
InteractionP42697:DRP1A; NbExp=4; IntAct=EBI-994222, EBI-994234;
MiscellaneousBinds to phosphatidylinositol (PI), phosphatidylinositol 4-monophosphate (PIP) and phosphatidylinositol 4,5-bisphosphate (PIP2) but not to phosphatidic acid (PA), phosphatidylcholine (PC) or phosphatidylethanolamine (PE).
Sequence CautionSequence=CAB86637.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityContains 1 Arf-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00288}.
SimilarityContains 1 BAR domain. {ECO:0000305}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 3 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular LocationGolgi apparatus, trans-Golgi network {ECO:0000269|PubMed:15743878}.
SubunitHomodimer. Interacts with DRP1A. {ECO:0000269|PubMed:15743878, ECO:0000269|PubMed:15923323}.
Tissue SpecificityDetected in roots, hypocotyls, cotyledons, leaves, siliques and shoot apical meristems. {ECO:0000269|PubMed:16698946}.