LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP009178

UniProt Annotations

Entry Information
Gene NameSphingosine-1-phosphate lyase
Protein EntrySGPL_DROME
UniProt IDQ9V7Y2
SpeciesDrosophila
Comments
Comment typeDescription
Catalytic ActivitySphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250};
Developmental StageExpressed both maternally and zygotically. Expression is high in early and late embryos, and then again early in metamorphosis, followed by reduction to basal levels after eclosion of adult flies in both males and females. {ECO:0000269|PubMed:12702658}.
FunctionCleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development. {ECO:0000269|PubMed:12702658}.
PathwayLipid metabolism; sphingolipid metabolism.
SimilarityBelongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
Tissue SpecificityLocalized to the developing gut primordium during embryogenesis. {ECO:0000269|PubMed:12702658}.