LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP009130

UniProt Annotations

Entry Information
Gene Namemelted
Protein EntryMELT_DROME
UniProt IDQ9VS24
SpeciesDrosophila
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=C; IsoId=Q9VS24-3; Sequence=Displayed; Name=B; IsoId=Q9VS24-2; Sequence=VSP_027438;
DomainThe PH domain is required for membrane targeting.
FunctionParticipates in fat metabolism regulation by recruiting FOXO and the TSC1-TSC2 complex to the cell membrane, which positively regulates TOR activity and negatively regulates the expression of FOXO target genes. Involved in R8 photoreceptor subtype specification. During early embryonic development, may be required for ectodermal patterning. {ECO:0000269|PubMed:11102367, ECO:0000269|PubMed:16054033, ECO:0000269|PubMed:16143107}.
SimilarityBelongs to the MELT/VEPH family. {ECO:0000305}.
SimilarityContains 1 PH domain.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:16054033}; Peripheral membrane protein {ECO:0000269|PubMed:16054033}; Cytoplasmic side {ECO:0000269|PubMed:16054033}.
SubunitInteracts with TSC1 and FOXO. {ECO:0000269|PubMed:16054033}.