LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP008938

UniProt Annotations

Entry Information
Gene Nameforkhead box, sub-group O
Protein EntryQ95V55_DROME
UniProt IDQ95V55
SpeciesDrosophila
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=B {ECO:0000269|PubMed:12893776}; Synonyms=C {ECO:0000269|PubMed:10731132}; IsoId=Q95V55-1; Sequence=Displayed; Name=A {ECO:0000269|PubMed:10731132}; IsoId=Q95V55-2; Sequence=VSP_053041; Note=No experimental confirmation available. {ECO:0000305}; Name=D {ECO:0000269|PubMed:10731132}; IsoId=Q95V55-3; Sequence=VSP_053040, VSP_053042; Note=No experimental confirmation available. {ECO:0000305}; Name=E {ECO:0000269|Ref.2}; IsoId=Q95V55-4; Sequence=VSP_053039, VSP_053043;
Disruption PhenotypeMutant foxo lacking Akt1 phosphorylation sites no longer responds to insulin inhibition, remains in the nucleus, and is constitutively active, inducing cell arrest. {ECO:0000269|PubMed:12893776}.
FunctionTranscription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself may function as one secondary messenger of insulin-regulated aging. Also regulates Lip4, homolog of human acid lipases, thereby acting as a key modulator of lipid metabolism by insulin signaling and integrates insulin responses to glucose and lipid homeostasis. {ECO:0000269|PubMed:12893776, ECO:0000269|PubMed:12908874, ECO:0000269|PubMed:15175753, ECO:0000269|PubMed:16054033, ECO:0000269|PubMed:18234213}.
InteractionQ8I9J6:HDAC4; NbExp=3; IntAct=EBI-500849, EBI-4288282;
Sequence CautionSequence=AAL13947.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityContains 1 fork-head DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00089}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:12893776, ECO:0000269|PubMed:15175753}. Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:12893776, ECO:0000269|PubMed:15175753}. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. {ECO:0000269|PubMed:12893776, ECO:0000269|PubMed:15175753}.
SubunitInteracts with melt. {ECO:0000269|PubMed:16054033}.