LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP008189

UniProt Annotations

Entry Information
Gene NameProtein BRE-3
Protein EntryBRE3_CAEEL
UniProt IDQ03562
SpeciesC. elegans
Comments
Comment typeDescription
Disruption PhenotypeWorms exhibit resistance to the Cry5B toxin produced by Bacillus thuringiensis. This is thought to be due to mutants having reduced population of glycolipids which are targeted by the Cry5B protein. Mutants also have reduced brood sizes at only 17% of wild-type N2. {ECO:0000269|PubMed:10924467, ECO:0000269|PubMed:12944392}.
FunctionGlycosyltransferase with a proposed role in glycosphingolipid biosynthesis. Involved in susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2, bre- 4 and bre-5. Has a role in determining brood size. {ECO:0000269|PubMed:10924467, ECO:0000269|PubMed:12944392}.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 2 family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:12944392}. Note=In punctate structures throughout the cell.
Tissue SpecificityEndothelial cells. {ECO:0000269|PubMed:12944392}.