LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007805

UniProt Annotations

Entry Information
Gene NameProtein FAT-1
Protein EntryFAT1_CAEEL
UniProt IDQ9NEQ0
SpeciesC. elegans
Comments
Comment typeDescription
FunctionOmega-3 fatty acid desaturase that acts on a range of substrates. Catalyzes the desaturation of linolenic acid (18:2n- 6), dihomo-gamma-linoleic acid (DHGLA) (20:3n-6), and arachidonic acid (20:4n-6), to generate gamma linolenic acid (18:3n-3), eicosatetraenoic acid (20:4n-3) and eicosapentaenoic acid (20:5n- 3) respectively. Although the enzyme has been suggested to act on glycerolipids, the precise nature of the fatty acid substrate is unknown. {ECO:0000269|PubMed:11972048, ECO:0000269|PubMed:14765186, ECO:0000269|PubMed:9037020}.
PathwayLipid metabolism; polyunsaturated fatty acid biosynthesis. {ECO:0000269|PubMed:11972048, ECO:0000269|PubMed:14765186, ECO:0000269|PubMed:9037020}.
SimilarityBelongs to the fatty acid desaturase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.