LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007793

UniProt Annotations

Entry Information
Gene NameProtein FAT-2
Protein EntryFAT2_CAEEL
UniProt IDG5EGA5
SpeciesC. elegans
Comments
Comment typeDescription
FunctionCatalyzes the desaturation of oleic acid (Delta(9)-18:1, or C18:1(n-9)) to linoleic acid (Delta(9,12)-18:2, or C18:2(n-6)). This desaturation event is essential for the synthesis of longer chain polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA, or C20:4(n-6)) and eicosapentaenoic acid (EPA, or C20:5(n- 3)). {ECO:0000269|PubMed:10775428, ECO:0000269|PubMed:11972048}.
PathwayLipid metabolism; polyunsaturated fatty acid biosynthesis. {ECO:0000269|PubMed:10775428, ECO:0000269|PubMed:11972048}.
SimilarityBelongs to the fatty acid desaturase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.