LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007662

UniProt Annotations

Entry Information
Gene Namecardiolipin synthase 1
Protein EntryCLSA_ECOLI
UniProt IDP0A6H8
SpeciesE. coli
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 7.0. {ECO:0000269|PubMed:1663113};
Catalytic Activity2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol. {ECO:0000255|HAMAP- Rule:MF_00190, ECO:0000269|PubMed:1663113, ECO:0000269|PubMed:19341704}.
Disruption PhenotypeMutants have increased sensitivity to novobiocin. Triple deletion of clsA, clsB and clsC results in a complete lack of cardiolipin, regardless of growth phase or growth conditions. {ECO:0000269|PubMed:19341704, ECO:0000269|PubMed:7665497}.
FunctionCatalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. {ECO:0000255|HAMAP-Rule:MF_00190, ECO:0000269|PubMed:1663113, ECO:0000269|PubMed:19341704}.
MiscellaneousAll three cardiolipin synthases (ClsA, ClsB and ClsC) contribute to CL synthesis in stationary phase. Only ClsA contributes to synthesis during logarithmic growth phase (PubMed:22988102). {ECO:0000305|PubMed:22988102}.
PtmSeems to be post-translationally processed from a 53-55 kDa form to a 45-46 kDa form (PubMed:7665497 and PubMed:19341704).
SimilarityBelongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily. {ECO:0000255|HAMAP- Rule:MF_00190}.
SimilarityContains 2 PLD phosphodiesterase domains. {ECO:0000255|HAMAP-Rule:MF_00190}.
Subcellular LocationCell inner membrane {ECO:0000255|HAMAP- Rule:MF_00190, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:1663113, ECO:0000269|PubMed:22988102}; Multi- pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00190, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:1663113, ECO:0000269|PubMed:22988102}.