LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007616

UniProt Annotations

Entry Information
Gene Namefatty acid metabolism regulon transcriptional regulator
Protein EntryFADR_ECOLI
UniProt IDP0A8V6
SpeciesE. coli
Comments
Comment typeDescription
DomainThe C-terminal domain bind acyl-CoA.
FunctionMultifunctional regulator of fatty acid metabolism. Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE. Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes. Binding of FadR is specifically inhibited by long chain fatty acyl-CoA compounds.
SimilarityContains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|HAMAP-Rule:MF_00696}.
Subcellular LocationCytoplasm {ECO:0000255|HAMAP-Rule:MF_00696}.
SubunitHomodimer.