LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007538

UniProt Annotations

Entry Information
Gene NameVta1p
Protein EntryVTA1_YEAST
UniProt IDQ06263
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionHas a role in the formation of the multivesicular body (MVB). Required for the sorting of lipids to form intralumenal vesicles and for fluid-phase transport to the vacuole. Required for sorting the plasma membrane proteins STE2 and STE3 into the MVB. Acts a cofactor of VSP4, promotes the oligomerization of VPS4 and stimulates its ATPase activity by 6- to 8-fold. {ECO:0000269|PubMed:12953057, ECO:0000269|PubMed:14701806, ECO:0000269|PubMed:16505166, ECO:0000269|PubMed:16601096}.
InteractionP52917:VPS4; NbExp=7; IntAct=EBI-37098, EBI-20475;
MiscellaneousPresent with 4400 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the VTA1 family. {ECO:0000305}.
Subcellular LocationCytoplasm. Endosome membrane; Peripheral membrane protein.
SubunitHomodimer (in cytoplasm). Interacts with VPS4; the interaction requires the dimeric structure of VTA1; 6 homodimers of VTA1 appear to associate with the dodecameric VSP4 complex; the interaction is ADP-dependent. Interacts with SNF7; the interaction requires DID2. Interacts with DID2. Interacts with VPS60; the interaction occurs at he endosomal membrane. {ECO:0000269|PubMed:12953057, ECO:0000269|PubMed:14701806, ECO:0000269|PubMed:15086794, ECO:0000269|PubMed:16505166, ECO:0000269|PubMed:16601096, ECO:0000269|PubMed:18032584, ECO:0000269|PubMed:18194651, ECO:0000269|PubMed:18194652, ECO:0000269|PubMed:18280501}.