LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007534

UniProt Annotations

Entry Information
Gene NameLpx1p
Protein EntryLPX1_YEAST
UniProt IDQ12405
SpeciesYeast (S288c)
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=6.3 uM for p-nitrophenyl butyrate (PNB) {ECO:0000269|PubMed:18199283}; Vmax=5.6 pmol/h/ug enzyme toward 1,2-dioleoyl-3-(pyren-1- yl)decanoyl-rac-glycerol (DPG) {ECO:0000269|PubMed:18199283}; Vmax=7.9 pmol/h/ug enzyme toward 1,2-bis-(4,4-difluoro-5,7- dimethyl-4-bora-3a,4a-diaza-sindacene-3-undecanoyl)-sn-glycero- 3-phosphocholine (BPC) {ECO:0000269|PubMed:18199283};
Biophysicochemical PropertiesKinetic parameters: KM=6.3 uM for p-nitrophenyl butyrate (PNB) ; Vmax=5.6 pmol/h/ug enzyme toward 1,2-dioleoyl-3-(pyren-1- yl)decanoyl-rac-glycerol (DPG) ; Vmax=7.9 pmol/h/ug enzyme toward 1,2-bis-(4,4-difluoro-5,7- dimethyl-4-bora-3a,4a-diaza-sindacene-3-undecanoyl)-sn-glycero- 3-phosphocholine (BPC) ;
Disruption PhenotypeAberrant morphology characterized by intraperoxisomal vesicles or invaginations
Disruption PhenotypeAberrant morphology characterized by intraperoxisomal vesicles or invaginations. {ECO:0000269|PubMed:18199283}.
FunctionHas acyl esterase, lipase and phospholipase A activity
FunctionHas acyl esterase, lipase and phospholipase A activity. {ECO:0000269|PubMed:18199283}.
InductionBy oleic acid. Transcriptionally up-regulated by YRM1 along with genes involved in multidrug resistance. Expression is also dependent on RSF1 and RSF2 for transcriptional induction during growth on glycerol-based medium. {ECO:0000269|PubMed:12135984, ECO:0000269|PubMed:14512416, ECO:0000269|PubMed:18199283, ECO:0000269|PubMed:19235764}.
MiscellaneousPresent with 2350 molecules/cell in log phase SD medium
MiscellaneousPresent with 2350 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Subcellular LocationPeroxisome matrix {ECO:0000269|PubMed:12135984, ECO:0000269|PubMed:18199283}. Note=Peroxisomal import is dependent on the peroxisomal targeting signal type 1 (PTS1) receptor PEX5 and on self-interaction.
Subcellular LocationPeroxisome matrix . Note=Peroxisomal import is dependent on the peroxisomal targeting signal type 1 (PTS1) receptor PEX5 and on self-interaction.