LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007517

UniProt Annotations

Entry Information
Gene NameAtg15p
Protein EntryATG15_YEAST
UniProt IDP25641
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityTriacylglycerol + H(2)O = diacylglycerol + a carboxylate.
FunctionLipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension. {ECO:0000269|PubMed:11085977, ECO:0000269|PubMed:11264288, ECO:0000269|PubMed:11566994, ECO:0000269|PubMed:12499386, ECO:0000269|PubMed:18690010, ECO:0000269|PubMed:21364763, ECO:0000269|PubMed:21777356}.
MiscellaneousPresent with 3060 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PtmGlycosylated. {ECO:0000269|PubMed:11085977, ECO:0000269|PubMed:11566994, ECO:0000269|PubMed:12499386}.
SimilarityBelongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Endosome, multivesicular body membrane; Single-pass type II membrane protein. Prevacuolar compartment membrane; Single-pass type II membrane protein. Note=From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC).
SubunitBinds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).