LMP007267 UniProt Annotations
Gene Name Vac14p Protein Entry VAC14_YEAST UniProt ID Q06708 Species Yeast (S288c)
Comment type Description Domain The N-terminal domain mediates interaction with FAB1 and VAC7 while the C-terminal domain mediates interaction with FIG4 Domain The N-terminal domain mediates interaction with FAB1 and VAC7 while the C-terminal domain mediates interaction with FIG4. {ECO:0000269|PubMed:19037259}. Function The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Regulates the synthesis of PtdIns(3,5)P2 by positive activation of FAB1 and by controlling FIG4 localization. Required for FIG4-mediated turnover of PtdIns(3,5)P2 after hyperosmotic shock. Essential for the control of trafficking of some proteins to the vacuole lumen via the multivesicular body (MVB), and for maintenance of vacuole size and acidity. {ECO:0000269|PubMed:11889142, ECO:0000269|PubMed:12062051, ECO:0000269|PubMed:14528018, ECO:0000269|PubMed:16492811, ECO:0000269|PubMed:19037259}. Interaction Self; NbExp=4; IntAct=EBI-27189, EBI-27189; P43601:ATG18; NbExp=5; IntAct=EBI-27189, EBI-22968; P34756:FAB1; NbExp=9; IntAct=EBI-27189, EBI-6754; P42837:FIG4; NbExp=7; IntAct=EBI-27189, EBI-28407; P53950:VAC7; NbExp=4; IntAct=EBI-27189, EBI-28714; Miscellaneous Present with 12388 molecules/cell in log phase SD medium Miscellaneous Present with 12388 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. Similarity Belongs to the VAC14 family Similarity Belongs to the VAC14 family. {ECO:0000305}. Similarity Contains 5 HEAT repeats. {ECO:0000255|PROSITE- ProRule:PRU00103}. Subcellular Location Vacuole membrane {ECO:0000269|PubMed:11889142, ECO:0000269|PubMed:14528018, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:18653468, ECO:0000269|PubMed:19037259}; Peripheral membrane protein {ECO:0000269|PubMed:11889142, ECO:0000269|PubMed:14528018, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:18653468, ECO:0000269|PubMed:19037259}. Note=Limiting membrane of the vacuole. Localization requires FAB1 and FIG4. Subunit Component of the PI(3,5)P2 regulatory complex, composed of ATG18, FIG4, FAB1, VAC14 and VAC7. VAC14 nucleates the assembly of the complex and serves as a scaffold Subunit Component of the PI(3,5)P2 regulatory complex, composed of ATG18, FIG4, FAB1, VAC14 and VAC7. VAC14 nucleates the assembly of the complex and serves as a scaffold. {ECO:0000269|PubMed:18653468, ECO:0000269|PubMed:19037259}.
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