LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007245

UniProt Annotations

Entry Information
Gene Namefatty acid elongase ELO2
Protein EntryELO2_YEAST
UniProt IDP25358
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityA very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2). {ECO:0000269|PubMed:12684876}.
DomainThe C-terminal di-lysine-like motif may confer endoplasmic reticulum localization. {ECO:0000303|PubMed:9832547}.
FunctionComponent of a microsomal membrane-bound long-chain fatty acid elongation system, which produces the 20-26-carbon very long-chain fatty acids (VLCFA) from long-chain fatty acid precursors and is involved ceramide and inositol sphingolipid biosynthesis. Component of elongase II, which elongates 16-18 carbon fatty acyl-CoAs such as palmitoyl-CoA and stearoyl-CoA to 20-22-carbon fatty acids by incorporation of malonyl-CoA (PubMed:9211877, PubMed:12684876). Involved in the synthesis of 1,3-beta-glucan (PubMed:7768822). {ECO:0000269|PubMed:12684876, ECO:0000269|PubMed:7768822, ECO:0000269|PubMed:9211877}.
InteractionQ05359:ERP1; NbExp=1; IntAct=EBI-6415, EBI-6581; P54837:ERV25; NbExp=1; IntAct=EBI-6415, EBI-6642; P38264:PHO88; NbExp=1; IntAct=EBI-6415, EBI-13350; P06197:PIS1; NbExp=1; IntAct=EBI-6415, EBI-13458; P39986:SPF1; NbExp=1; IntAct=EBI-6415, EBI-3128; P38992:SUR2; NbExp=1; IntAct=EBI-6415, EBI-18574; Q02795:SWP1; NbExp=1; IntAct=EBI-6415, EBI-12666; P38800:YHR080C; NbExp=1; IntAct=EBI-6415, EBI-24597;
MiscellaneousPresent with 3510 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the ELO family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:9832547}; Multi- pass membrane protein {ECO:0000255}.