LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007244

UniProt Annotations

Entry Information
Gene NameSlm2p
Protein EntrySLM2_YEAST
UniProt IDP53955
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionTogether with SLM1, effector of the TORC2- and calcineurin-signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin, inhibiting interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis. {ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497, ECO:0000269|PubMed:16738335}.
InteractionP43603:LSB3; NbExp=2; IntAct=EBI-28706, EBI-22980;
MiscellaneousPresent with 2610 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:15023338, ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497}; Peripheral membrane protein {ECO:0000269|PubMed:15023338, ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497}; Cytoplasmic side {ECO:0000269|PubMed:15023338, ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497}.
SubunitHeterodimer of SLM1-SLM2. Binds phosphatidylinositol 4,5- bisphosphate, which is required for function. Interacts with the TORC2 subunits AVO2, BIT61 and TOR2. Interacts with the calcineurin catalytic subunits CNA1 and CNA2. {ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497, ECO:0000269|PubMed:16738335}.