LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007207

UniProt Annotations

Entry Information
Gene NameErg28p
Protein EntryERG28_YEAST
UniProt IDP40030
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionHas a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. May also be responsible for facilitating their interaction. {ECO:0000269|PubMed:11160377}.
InteractionP53045:ERG25; NbExp=3; IntAct=EBI-22518, EBI-6506; P53199:ERG26; NbExp=3; IntAct=EBI-22518, EBI-6514; Q12452:ERG27; NbExp=6; IntAct=EBI-22518, EBI-38132;
MiscellaneousPresent with 377 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the ERG28 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305|PubMed:12119386}; Multi-pass membrane protein {ECO:0000305|PubMed:12119386}.
SubunitHeterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation- related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum. Interacts with ERG25, ERG26 and ERG27. Also interacts with ERG1, ERG3, ERG5, ERG6 and ERG11. {ECO:0000269|PubMed:12119386, ECO:0000269|PubMed:15522820, ECO:0000269|PubMed:15995173}.