LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007079

UniProt Annotations

Entry Information
Gene NameFpk1p
Protein EntryFPK1_YEAST
UniProt IDP53739
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
Enzyme RegulationDown-regulated by YKP1 phosphorylation. This effect is counteracted in the presence of mannosyl- inositolphosphorylceramide (MIPC). {ECO:0000269|PubMed:19966303}.
FunctionFlippase activator that phosphorylates DFN1 and DFN2 and which is involved in the generation of phospholipid asymmetry in membranes by the inward translocation of phospholipids and in the retrieval pathway from early endosomes to the trans-Golgi network (TGN). Phosphorylates also the N-terminal half of YPK1. Involved in pheromone-response. {ECO:0000269|PubMed:11337509, ECO:0000269|PubMed:18199685, ECO:0000269|PubMed:19966303}.
MiscellaneousPresent with 752 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PtmThe N-terminal non-catalytic domain is phosphorylated by YPK1. {ECO:0000269|PubMed:17330950, ECO:0000269|PubMed:18407956, ECO:0000269|PubMed:19779198, ECO:0000269|PubMed:19966303}.
SimilarityBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. KIN82 subfamily. {ECO:0000255|PROSITE- ProRule:PRU00159}.
SimilarityContains 1 AGC-kinase C-terminal domain. {ECO:0000305}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:14562095}. Cell membrane {ECO:0000269|PubMed:14562095}; Peripheral membrane protein {ECO:0000269|PubMed:14562095}.