LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007070

UniProt Annotations

Entry Information
Gene Nameglucan 1,3-alpha-glucosidase ROT2
Protein EntryGLU2A_YEAST
UniProt IDP38138
SpeciesYeast (S288c)
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 5.8-6.8. ;
Biophysicochemical PropertiespH dependence: Optimum pH is 5.8-6.8. {ECO:0000269|PubMed:6216253};
Catalytic ActivityHydrolysis of terminal (1->3)-alpha-D- glucosidic links in (1->3)-alpha-D-glucans.
Enzyme RegulationInhibited by glucose, maltose and nigerose, and by the antibiotic deoxynojirimycin.
FunctionCatalytic subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. {ECO:0000269|PubMed:16373354, ECO:0000269|PubMed:8910335}.
InteractionQ04924:GTB1; NbExp=1; IntAct=EBI-21021, EBI-37493;
MiscellaneousPresent with 238 molecules/cell in log phase SD medium
MiscellaneousPresent with 238 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayGlycan metabolism; N-glycan metabolism.
SimilarityBelongs to the glycosyl hydrolase 31 family
SimilarityBelongs to the glycosyl hydrolase 31 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum .
Subcellular LocationEndoplasmic reticulum {ECO:0000269|PubMed:16373354}.
SubunitHeterodimer of a catalytic subunit alpha (ROT2) and a subunit beta (GTB1).