LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007041

UniProt Annotations

Entry Information
Gene Nameinositol phosphosphingolipid phospholipase
Protein EntryISC1_YEAST
UniProt IDP40015
SpeciesYeast (S288c)
Comments
Comment typeDescription
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
FunctionResponsible for the hydrolysis of the phosphosphingolipids (IPS), inositol phosphorylceramide (IPC), mannosylinositol phosphorylceramide (MIPC), and mannosyldiinositol phosphorylceramide (M(IP)2C). Also active on sphingomyelin, but this activity is probably not physiologically relevant.
InteractionP25376:AGP1; NbExp=1; IntAct=EBI-9371, EBI-2357; P40975:PMP2; NbExp=1; IntAct=EBI-9371, EBI-2043041;
MiscellaneousPresent with 2170 molecules/cell in log phase SD medium
MiscellaneousPresent with 2170 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayLipid metabolism; sphingolipid metabolism.
SimilarityBelongs to the neutral sphingomyelinase family
SimilarityBelongs to the neutral sphingomyelinase family. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.