LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007006

UniProt Annotations

Entry Information
Gene NameKap95p
Protein EntryIMB1_YEAST
UniProt IDQ06142
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionRequired for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Serves a receptor for nuclear localization signals. Mediates the nuclear import of histones H2A and H2B
FunctionRequired for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Serves a receptor for nuclear localization signals. Mediates the nuclear import of histones H2A and H2B. {ECO:0000269|PubMed:11309407}.
InteractionP14907:NSP1; NbExp=3; IntAct=EBI-9145, EBI-12265; P20676:NUP1; NbExp=6; IntAct=EBI-9145, EBI-12392; Q02629:NUP100; NbExp=4; IntAct=EBI-9145, EBI-11698; Q02630:NUP116; NbExp=4; IntAct=EBI-9145, EBI-11703; P40477:NUP159; NbExp=3; IntAct=EBI-9145, EBI-11747; P32499:NUP2; NbExp=5; IntAct=EBI-9145, EBI-12401; P49686:NUP42; NbExp=2; IntAct=EBI-9145, EBI-12310; Q02199:NUP49; NbExp=2; IntAct=EBI-9145, EBI-12315; P48837:NUP57; NbExp=2; IntAct=EBI-9145, EBI-12324; P39705:NUP60; NbExp=4; IntAct=EBI-9145, EBI-20731; Q02821:SRP1; NbExp=5; IntAct=EBI-9145, EBI-1797;
MiscellaneousBinds to nucleoporin FxFG but not GLFG repeat regions. Ran-GTP can disrupt the karyopherin heterodimer by binding to the beta subunit and releases both subunits from the docking site.
MiscellaneousPresent with 51700 molecules/cell in log phase SD medium
MiscellaneousPresent with 51700 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
MiscellaneousThe stoichiometric complex between the beta subunit and Ran-GTP renders the latter inaccessible to Ran-specific GTPase activating protein (Ran-GAP) thereby inhibiting GTP hydrolysis stimulated by Ran-GAP.
SimilarityBelongs to the importin beta family
SimilarityBelongs to the importin beta family. {ECO:0000305}.
SimilarityContains 1 importin N-terminal domain
SimilarityContains 1 importin N-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00115}.
SimilarityContains 8 HEAT repeats. {ECO:0000255|PROSITE- ProRule:PRU00103}.
Subcellular LocationCytoplasm {ECO:0000250}. Nucleus envelope {ECO:0000250}.
Subcellular LocationCytoplasm . Nucleus envelope .
SubunitForms a complex with importin alpha subunit.