LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP006967

UniProt Annotations

Entry Information
Gene Nameacetate--CoA ligase ACS2
Protein EntryACS2_YEAST
UniProt IDP52910
SpeciesYeast (S288c)
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=8.8 mM for acetate {ECO:0000269|PubMed:8910545}; KM=1.3 mM for ATP {ECO:0000269|PubMed:8910545}; Vmax=0.34 umol/min/mg enzyme {ECO:0000269|PubMed:8910545};
Biophysicochemical PropertiesKinetic parameters: KM=8.8 mM for acetate ; KM=1.3 mM for ATP ; Vmax=0.34 umol/min/mg enzyme ;
Catalytic ActivityATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
FunctionCatalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. "Anaerobic" isozyme of acetyl-coenzyme A synthetase, which is required for growth on fermentable carbon sources such as glucose. May be involved in the PDH (pyruvate dehydrogenase complex) bypass
FunctionCatalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. "Anaerobic" isozyme of acetyl-coenzyme A synthetase, which is required for growth on fermentable carbon sources such as glucose. May be involved in the PDH (pyruvate dehydrogenase complex) bypass. {ECO:0000269|PubMed:16857587, ECO:0000269|PubMed:8910545}.
MiscellaneousPresent with 225000 molecules/cell in log phase SD medium
MiscellaneousPresent with 225000 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayCarbohydrate metabolism; pyruvate metabolism.
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular LocationCytoplasm. Nucleus. Note=Predominantly nuclear.