LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP006895

UniProt Annotations

Entry Information
Gene Nameprotein geranylgeranyltransferase type I subunit CDC43
Protein EntryPGTB1_YEAST
UniProt IDP18898
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityGeranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
FunctionCatalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal sequence Cys-Ile-Ile-Leu or Cys-Val-Leu-Leu. Acts, among other substrates, on Rho1 and Rho2 and CDC42 proteins. Participates in a RAS-like C-terminal modification of proteins involved in nuclear division and bud growth. It is involved in bud positioning and cell polarity. {ECO:0000269|PubMed:2034682}.
InteractionP29703:RAM2; NbExp=3; IntAct=EBI-3961, EBI-14814;
MiscellaneousPresent with 3940 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the protein prenyltransferase subunit beta family. {ECO:0000305}.
SimilarityContains 4 PFTB repeats. {ECO:0000305}.
SubunitHeterodimer of an alpha and a beta subunit.