LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP006822

UniProt Annotations

Entry Information
Gene NamePlb2p
Protein EntryPLB2_YEAST
UniProt IDQ03674
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
FunctionSequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine > phosphatidylinositol > phosphatidylcholine > phosphatidylethanolamine
FunctionSequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine > phosphatidylinositol > phosphatidylcholine > phosphatidylethanolamine. {ECO:0000269|PubMed:10497163}.
InteractionP38800:YHR080C; NbExp=1; IntAct=EBI-2079187, EBI-24597;
MiscellaneousPresent with 623 molecules/cell in log phase SD medium
MiscellaneousPresent with 623 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PtmThe GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
SimilarityBelongs to the lysophospholipase family
SimilarityBelongs to the lysophospholipase family. {ECO:0000305}.
SimilarityContains 1 PLA2c domain. {ECO:0000255|PROSITE- ProRule:PRU00555}.
Subcellular LocationSecreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP).