LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP006578

UniProt Annotations

Entry Information
Gene Namelipocalin 5
Protein EntryA2AJB7_MOUSE
UniProt IDA2AJB7
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1 ; IsoId=A2AJB7-1; Sequence=Displayed; Name=2 ; IsoId=A2AJB7-2; Sequence=VSP_052839; Note=No experimental confirmation available. ; Name=3 ; IsoId=A2AJB7-3; Sequence=VSP_052840; Note=No experimental confirmation available. ; Name=4 ; IsoId=A2AJB7-4; Sequence=VSP_052838;
FunctionAssociates with spermatozoa in the epididymal fluid but does not bind tightly to them. Binds both all-trans and 13-cis retinoic acid. May act as a retinoid carrier protein which is required for epididymal function and/or sperm maturation.
InductionDown-regulated to 11% of control levels 5 days after castration and is not detectable by 20 days (at protein level). Levels are partially restored by subsequent testosterone treatment.
Ptm2 different forms with differently processed N-termini exist.
Sequence CautionSequence=AAD09351.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the calycin superfamily. Lipocalin family.
Subcellular LocationSecreted {ECO:0000269|PubMed:1591332, ECO:0000269|PubMed:2393684}. Note=Synthesized by the mid and distal caput of the epididymis and secreted into the epididymal lumen.
Tissue SpecificityEpididymal fluid of the caudal and corpus regions (at protein level).