LMP002007 UniProt Annotations
Gene Name cytochrome P450, family 4, subfamily F, polypeptide 2
Protein Entry CP4F2_HUMAN
UniProt ID P78329
Species Human
Comment type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P78329-1; Sequence=Displayed; Name=2; IsoId=P78329-2; Sequence=VSP_055578, VSP_055579, VSP_055580; Note=No experimental confirmation available.;
Biophysicochemical Properties Kinetic parameters: KM=74.8 uM for leukotriene-B(4) ; KM=1.7 uM for menaquinone-4 (MK-4) ; Vmax=2.42 nmol/min/mg enzyme ; Note=kcat is 0.067 min(-1) with menaquinone-4 (MK-4) as substrate ;
Catalytic Activity (5Z,8Z,11Z,14Z)-icosatetraenoate + NADPH + O(2) = (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoate + NADP(+) + H(2)O.
Catalytic Activity (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa- 6,8,10,14-tetraenoate + NADPH + O(2) = (6Z,8E,10E,14Z)-(5S,12R)- 5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)O.
Catalytic Activity Phylloquinone + NADPH + O(2) = omega- hydroxyphylloquinone + NADP(+) + H(2)O.
Cofactor Name=heme; Xref=ChEBI
Disease Coumarin resistance (CMRES) [MIM
Function Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531). Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), possibly influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070). Also acts as a leukotriene-B(4) omega-hydroxylase by mediating conversion of leukotriene-B(4) (LTB4) to its omega-hydroxylated metabolite 20-hydroxyleukotriene- B(4) (20-OH LTB4) (PubMed:8026587, PubMed:9799565). {ECO
Interaction P16333:NCK1; NbExp=2; IntAct=EBI-1752413, EBI-389883;
Pathway Cofactor degradation; phylloquinone degradation.
Similarity Belongs to the cytochrome P450 family.
Subcellular Location Microsome membrane {ECO
Tissue Specificity Liver. Also present in kidney: specifically expressed in the S2 and S3 segments of proximal tubules in cortex and outer medulla (PubMed:10660572). {ECO
Web Resource Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cyp4f2/";
We use Cookies
This site uses cookies and other tracking technologies to assist with navigation and your ability to provide feedback, analyze your use of our products and services, assist with our promotional and marketing efforts, and provide content from third parties.
More Options
Accept