LIPID MAPS® Gene/Proteome Database (LMPD)

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LMP001770

Record overview

LMPD IDLMP001770
Gene ID3995
SpeciesHomo sapiens (Human)
Gene Namefatty acid desaturase 3
Gene SymbolFADS3
SynonymsCYB5RP; LLCDL3
Alternate namesfatty acid desaturase 3; delta-9-desaturase; cytochrome b5-related protein; delta-9 fatty acid desaturase; linoleoyl-CoA desaturase (delta-9-desaturase)-like 3
Chromosome11
Map Location11q12-q13.1
EC Number1.14.19.-
SummaryThe protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for FADS3

Proteins

fatty acid desaturase 3
Refseq ID:NP_068373
Protein GI:13375616
UniProt ID:Q9Y5Q0
mRNA ID:NM_021727
Length:445
RefSeq Status:REVIEWED
MGGVGEPGPREGPAQPGAPLPTFCWEQIRAHDQPGDKWLVIERRVYDISRWAQRHPGGSRLIGHHGAEDATDAFRAFHQDLNFVRKFLQPLLIGELAPEE
PSQDGPLNAQLVEDFRALHQAAEDMKLFDASPTFFAFLLGHILAMEVLAWLLIYLLGPGWVPSALAAFILAISQAQSWCLQHDLGHASIFKKSWWNHVAQ
KFVMGQLKGFSAHWWNFRHFQHHAKPNIFHKDPDVTVAPVFLLGESSVEYGKKKRRYLPYNQQHLYFFLIGPPLLTLVNFEVENLAYMLVCMQWADLLWA
ASFYARFFLSYLPFYGVPGVLLFFVAVRVLESHWFVWITQMNHIPKEIGHEKHRDWVSSQLAATCNVEPSLFTNWFSGHLNFQIEHHLFPRMPRHNYSRV
APLVKSLCAKHGLSYEVKPFLTALVDIVRSLKKSGDIWLDAYLHQ