LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP001513

UniProt Annotations

Entry Information
Gene Nameinositol 1,4,5-trisphosphate receptor, type 2
Protein EntryITPR2_HUMAN
UniProt IDQ14571
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q14571-1; Sequence=Displayed; Name=Short; Synonyms=TIPR; IsoId=Q14571-2; Sequence=VSP_002699, VSP_002700;
DomainThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
FunctionReceptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity).
MiscellaneousCalcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium- binding protein which then inhibits the receptor.
PtmPhosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
SimilarityBelongs to the InsP3 receptor family.
SimilarityContains 5 MIR domains. {ECO
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein.
SubunitHomotetramer (By similarity). Interacts with CABP1.
Tissue SpecificityIsoform Short is found in skeletal muscle and heart.