LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP001213

UniProt Annotations

Entry Information
Gene Nameapolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
Protein EntryABEC1_HUMAN
UniProt IDP41238
SpeciesHuman
Comments
Comment typeDescription
CofactorName=Zn(2+); Xref=ChEBI
FunctionCatalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
SimilarityBelongs to the cytidine and deoxycytidylate deaminase family.
Subcellular LocationCytoplasm .
SubunitHomodimer. Part of the apolipoprotein B mRNA editing complex with A1CF. Found in a complex with CELF2/CUGBP2 and A1CF. Interacts with HNRPAB and SYNCRIP. {ECO
Tissue SpecificityExpressed exclusively in the small intestine.