Irisflorentin is an isoflavone that has been found in B. chinensis and has anti-inflammatory and cytoprotective activities.^1,2,3 It reduces LPS-induced increases in the levels of nitric oxide (NO), inducible NO synthase (iNOS), TNF-α, IL-1β, and IL-6 in RAW 264.7 macrophages at 10, 20, and 40 µM.¹ Irisflorentin increases phagocytosis of E. coli by RAW 264.7 macrophages at 40 µM and prevents M1 polarization in mouse bone marrow-derived macrophages (BMDMs).² It also reduces the secretion of IL-6, TNF-α, and IL-10 induced by heat-inactivated methicillin-resistant S. aureus (HK-MRSA) in mouse BMDMs. Irisflorentin activates the PI3K, mTOR, and BDNF signaling pathways, increases cell viability, and reduces lactate dehydrogenase (LDH) release, reactive oxygen species (ROS) production, and apoptosis in a PC12 cellular model of ischemic stroke using oxygen-glucose deprivation and reoxygenation.³