LMPD Database

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LMP014311

UniProt Annotations

Entry Information
Gene Namelipoprotein, Lp(a)
Protein Entry
UniProt ID
SpeciesRhesus monkey
Comments
Comment typeDescription
DiseaseNote=Elevated plasma concentrations of apo(a) and its naturally occurring proteolytic fragments are correlated with atherosclerosis. Homology with plasminogen kringles IV and V is thought to underlie the atherogenicity of the protein, because the fragments are competing with plasminogen for fibrin(ogen) binding.
FunctionApo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.
MiscellaneousApo(a) is known to be proteolytically cleaved, leading to the formation of the so-called mini-Lp(a). Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis. O-glycosylation may limit the extent of proteolytic fragmentation (By similarity). {ECO:0000250}.
PtmN- and O-glycosylated. {ECO:0000250}.
SimilarityBelongs to the peptidase S1 family. Plasminogen subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
SimilarityContains 1 peptidase S1 domain. {ECO:0000255|PROSITE- ProRule:PRU00274}.
SimilarityContains at least 10 kringle domains. {ECO:0000305}.
SubunitDisulfide-linked to apo-B100. Binds to fibronectin and decorin (By similarity). {ECO:0000250}.