LMPD Database

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LMP013560

UniProt Annotations

Entry Information
Gene NameN-acylethanolamine acid amidase
Protein EntryNAAA_RAT
UniProt IDQ5KTC7
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=35 uM for N-palmitoylethanolamine ; pH dependence: Optimum pH is 5 with N-palmitoylethanolamine as substrate. ;
Enzyme RegulationStimulated by DTT and Triton X-100
FunctionDegrades bioactive fatty acid amides to their corresponding acids, with the following preference: N- palmitoylethanolamine > N-myristoylethanolamine > N- stearoylethanolamine > N-oleoylethanolamine > N- linoleoylethanolamine > N-arachidonoylethanolamine
PtmAutoproteolytic cleavage in the acidic lumen of the lysosome activates the enzyme
SimilarityBelongs to the acid ceramidase family
Subcellular LocationLysosome .
SubunitHeterodimer of an alpha and a beta subunit, non- covalently linked
Tissue SpecificityExpressed in brain, cecum, colon, heart, ileum, kidney, liver, lung, spleen, stomach, submaxillary gland, testis and thymus