LMPD Database

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LMP013524

UniProt Annotations

Entry Information
Gene Namecytochrome b5 reductase 2
Protein EntryNB5R2_RAT
UniProt IDQ6AY12
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityNADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence= ;
FunctionNADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2- [4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1) (By similarity)
SimilarityBelongs to the flavoprotein pyridine nucleotide cytochrome reductase family
SimilarityContains 1 FAD-binding FR-type domain