LMPD Database

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LMP013511

UniProt Annotations

Entry Information
Gene Namepleckstrin homology-like domain, family A, member 3
Protein EntryPHLA3_RAT
UniProt IDQ5PQT7
SpeciesRat
Comments
Comment typeDescription
DomainThe PH domain binds phosphoinositides with a broad specificity. It competes with the PH domain of AKT1 and directly interferes with AKT1 binding to phosphatidylinositol 4,5- bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3), preventing AKT1 association to membrane lipids and subsequent activation of AKT1 signaling (By similarity)
Functionp53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor (By similarity)
SimilarityBelongs to the PHLDA3 family
SimilarityContains 1 PH domain
Subcellular LocationCytoplasm . Membrane {ECO:0000250}; Peripheral membrane protein .