LMPD Database

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LMP013478

UniProt Annotations

Entry Information
Gene NameALG6, alpha-1,3-glucosyltransferase
Protein EntryALG6_RAT
UniProt IDQ3T1L5
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityDolichyl beta-D-glucosyl phosphate + D-Man- alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha- (1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))- D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D- GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)- D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man- alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha- (1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc- diphosphodolichol + dolichyl phosphate.
FunctionAdds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol (By similarity)
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the ALG6/ALG8 glucosyltransferase family
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein .