LMPD Database

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LMP013434

UniProt Annotations

Entry Information
Gene Namemetallophosphoesterase 1
Protein EntryMPPE1_RAT
UniProt IDB1WC86
SpeciesRat
Comments
Comment typeDescription
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Note=Binds 2 manganese ions per subunit. ;
FunctionMetallophosphoesterase required for transport of GPI- anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins (By similarity)
SimilarityBelongs to the metallophosphoesterase superfamily. MPPE1 family
Subcellular LocationGolgi apparatus, cis-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Multi-pass membrane protein . Note=Also localizes to endoplasmic reticulum exit site
SubunitInteracts with GPI-anchor proteins. Interacts with TMED10 (By similarity)