LMPD Database

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LMP013415

UniProt Annotations

Entry Information
Gene Namecarbonyl reductase 4
Protein EntryCBR4_RAT
UniProt IDQ7TS56
SpeciesRat
Comments
Comment typeDescription
FunctionThe heteroteramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (By similarity)
PathwayLipid metabolism; fatty acid biosynthesis.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family
Subcellular LocationMitochondrion matrix .
SubunitHomotetramer. Heterotetramer with HSD17B8; contains two molecules of HSD17B8 and CBR4 (By similarity)