LMPD Database

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LMP013233

UniProt Annotations

Entry Information
Gene Nameectonucleotide pyrophosphatase/phosphodiesterase 7
Protein EntryENPP7_RAT
UniProt IDQ5EZ72
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 9.0. ;
Catalytic ActivitySphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
FunctionConverts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity.
PtmN-glycosylated; required for activity and transport to the plasma membrane
SimilarityBelongs to the nucleotide pyrophosphatase/phosphodiesterase family
Subcellular LocationMembrane ; Single-pass type I membrane protein . Note=Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex
Tissue SpecificityHighly expressed in the jejunum