LMPD Database

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LMP013102

UniProt Annotations

Entry Information
Gene Nameseptin 1
Protein EntrySEPT1_RAT
UniProt IDQ5EB96
SpeciesRat
Comments
Comment typeDescription
FunctionFilament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). {ECO:0000250, ECO:0000305}.
SimilarityBelongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Septin GTPase family
SimilarityContains 1 septin-type G (guanine nucleotide-binding) domain
Subcellular LocationCytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody . Note=Remains at the centrosomes and the nearby microtubules throughout mitosis. Localizes to the midbody during cytokinesis (By similarity)
SubunitSeptins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with AURKB (By similarity)