LMPD Database

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LMP013073

UniProt Annotations

Entry Information
Gene Namealdehyde dehydrogenase 7 family, member A1
Protein EntryAL7A1_RAT
UniProt IDQ64057
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityAn aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
Catalytic ActivityBetaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
Catalytic Activity(S)-2-amino-6-oxohexanoate + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H.
FunctionMultifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity)
PathwayAmine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
SimilarityBelongs to the aldehyde dehydrogenase family
Subcellular LocationNucleus . Cytoplasm, cytosol {ECO:0000250}. Mitochondrion .
SubunitHomotetramer
Tissue SpecificityAbundant in kidney, liver, cochlea and outer hair cells but not inner hair cells or vestibular type I hair cells. Very low levels in lung, brain, intestine and pancreas