LMPD Database

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LMP013068

UniProt Annotations

Entry Information
Gene Namealdo-keto reductase family 1, member C2
Protein EntryAK1CL_RAT
UniProt IDQ6AYQ2
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityAndrosterone + NAD(P)(+) = 5-alpha-androstane- 3,17-dione + NAD(P)H.
FunctionNADP-dependent 17-alpha-hydroxysteroid dehydrogenase that converts 5-alpha-androstane-3,17-dione into androsterone. Has lower 3-alpha-hydroxysteroid dehydrogenase activity. Has broad substrate specificity and acts on various 17-alpha- hydroxysteroids, 17-ketosteroids, 3-alpha hydroxysteroids and 3- ketosteroids. Reduction of keto groups is strictly stereoselective. Reduction of 17-ketosteroids yields only 17- alpha-hydroxysteroids. Likewise, reduction of 3-ketosteroids yields only 3-alpha-hydroxysteroids (By similarity)
SimilarityBelongs to the aldo/keto reductase family
Subcellular LocationCytoplasm .
SubunitMonomer